[Anesthesia by injection of xylazine, ketamine and the benzodiazepine derivative climazolam and the use of the benzodiazepine antagonist Ro 15-3505].

25 horses which entered the clinic for minor surgery, received ketamine (2.2 mg/kg i.v.) for induction of anesthesia after previous sedation with xylazine (1.1 mg/kg i.v.). As soon as the horses were in the lateral recumbency, the benzodiazepine derivate climazolam was administered at a dose of 0.1 mg/kg i.v. (10 horses) or 0.2 mg/kg i.v. (15 horses). The anesthesia was maintained with repeated injections of ketamine (1.1 mg/kg i.v. every 9-12 minutes). At the end of the surgery, 20 minutes after the last ketamine injection, Ro 15-3505, a benzodiazepine antagonist, was injected at a dose of 0.01 mg/kg i.v. or 0.02 mg/kg i.v. Climazolam successfully suppressed the adverse reactions of ketamine, such as poor muscle relaxation, hyperacusis and convulsions. The benzodiazepine antagonist Ro 15-3505 allowed good control of the duration of anesthesia and--in most cases--a smooth, predictable recovery period was the result.
AuthorsB Kaegi
JournalSchweizer Archiv für Tierheilkunde (Schweiz Arch Tierheilkd) Vol. 132 Issue 5 Pg. 251-7 ( 1990) ISSN: 0036-7281 [Print] SWITZERLAND
Vernacular TitleInjektionsanästhesie mit Xylazin, Ketamin und dem Benzodiazepinderivat Climazolam sowie Anwendung des Benzodiazepinantagonisten Ro 15-3505.
PMID1975121 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Anxiety Agents
  • Benzodiazepinones
  • Benzodiazepines
  • Xylazine
  • Ketamine
  • Ro 15-3505
  • climazolam
  • Midazolam
  • Anesthesia (veterinary)
  • Animals
  • Anti-Anxiety Agents
  • Benzodiazepines (antagonists & inhibitors)
  • Benzodiazepinones
  • Female
  • Horses (physiology)
  • Ketamine
  • Male
  • Midazolam (analogs & derivatives)
  • Xylazine

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