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Effect of mitiglinide on Streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study based on ultra-performance liquid chromatography-tandem mass spectrometry.

Abstract
Mitiglinide is a new insulinotropic agent of the glinide class and its precise mechanism is not very clear yet. In this study, a urinary metabonomics method based on ultra-performance liquid chromatography-tandem mass spectrometry was developed to study the effect mechanism of mitiglinide on type 2 diabetes mellitus. With pattern recognition analysis of urinary metabolite profiles, a clear separation between Streptozotocin-induced type 2 diabetic rats and those treated with mitiglinide was achieved. Some significantly changed metabolites like citrate, creatinine, phenylalanine and bile acids (cholic acid, chenodeoxycholic acid and deoxycholic acid) have been identified and used to explain the mechanism. This work shows that metabonomics method is a valuable tool in drug mechanism study.
AuthorsShuang Cai, Taoguang Huo, Jinghua Xu, Xiumei Lu, Shuning Zheng, Famei Li
JournalJournal of chromatography. B, Analytical technologies in the biomedical and life sciences (J Chromatogr B Analyt Technol Biomed Life Sci) Vol. 877 Issue 29 Pg. 3619-24 (Nov 01 2009) ISSN: 1873-376X [Electronic] Netherlands
PMID19748326 (Publication Type: Journal Article)
Chemical References
  • Isoindoles
  • mitiglinide
Topics
  • Animals
  • Chromatography, Liquid (methods)
  • Diabetes Mellitus, Experimental (drug therapy, urine)
  • Diabetes Mellitus, Type 2 (drug therapy, urine)
  • Isoindoles (therapeutic use)
  • Male
  • Metabolomics (methods)
  • Rats
  • Rats, Wistar
  • Tandem Mass Spectrometry (methods)

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