Abstract |
Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.
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Authors | Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Cameron West, Amadeo Pesce, Patrick Friel |
Journal | Therapeutic drug monitoring
(Ther Drug Monit)
Vol. 31
Issue 6
Pg. 749-52
(Dec 2009)
ISSN: 1536-3694 [Electronic] United States |
PMID | 19745789
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Opioid
- Morphine Derivatives
- Morphine
- Glucuronidase
- 6-O-monoacetylmorphine
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Topics |
- Analgesics, Opioid
(metabolism, standards, urine)
- Analytic Sample Preparation Methods
- Chromatography, High Pressure Liquid
(methods)
- Glucuronidase
(metabolism)
- Humans
- Hydrolysis
- Morphine
(metabolism, standards, urine)
- Morphine Derivatives
(standards, urine)
- Pain
(urine)
- Reference Values
- Spectrometry, Mass, Electrospray Ionization
- Substance Abuse Detection
(standards)
- Tandem Mass Spectrometry
(methods)
- United States
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