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6-Acetylmorphine detected in the absence of morphine in pain management patients.

Abstract
Liquid chromatography tandem mass spectrometry was used to identify and confirm the presence of 6-acetylmorphine and morphine in 22,361 urines of pain management patients. Thirty urines tested positive for 6-acetylmorphine above a cutoff of 10 ng/mL. Twenty-three percent of the patients with urinary concentrations of 6-acetylmorphine above 10 ng/mL had urinary morphine concentrations below 300 ng/mL.
AuthorsBridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Cameron West, Amadeo Pesce, Patrick Friel
JournalTherapeutic drug monitoring (Ther Drug Monit) Vol. 31 Issue 6 Pg. 749-52 (Dec 2009) ISSN: 1536-3694 [Electronic] United States
PMID19745789 (Publication Type: Journal Article)
Chemical References
  • Analgesics, Opioid
  • Morphine Derivatives
  • Morphine
  • Glucuronidase
  • 6-O-monoacetylmorphine
Topics
  • Analgesics, Opioid (metabolism, standards, urine)
  • Analytic Sample Preparation Methods
  • Chromatography, High Pressure Liquid (methods)
  • Glucuronidase (metabolism)
  • Humans
  • Hydrolysis
  • Morphine (metabolism, standards, urine)
  • Morphine Derivatives (standards, urine)
  • Pain (urine)
  • Reference Values
  • Spectrometry, Mass, Electrospray Ionization
  • Substance Abuse Detection (standards)
  • Tandem Mass Spectrometry (methods)
  • United States

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