Abstract | AIM: METHODS: Seventy patients with liver cirrhosis and portal hypertension were prospectively studied. Indication for laparoscopic splenectomy was bleeding tendency in 10 patients, induction of interferon in 45, treatment of hepatocellular carcinoma in seven, and treatment for endoscopic injection sclerotherapy-resistant esophagogastric varices in eight. The severity of PHG was classified into none, mild, or severe according to the classification by McCormack et al. The severity of liver disease was classified using the Child-Pugh score. All patients underwent upper gastrointestinal endoscopy before and 1 month after the operation. RESULTS: The prevalence of PHG was significantly correlated with the severity of liver disease using the Child-Pugh score. The severity of PHG was significantly correlated with the resected spleen volume. One month after the operation, PHG was improved in 16 of 17 patients with severe PHG and in 12 of 32 with mild PHG. The Child-Pugh score showed a significant improvement (6.8 +/- 1.4 to 6.2 +/- 1.2) at 3 months after laparoscopic splenectomy (P < 0.0001). CONCLUSIONS: PHG may be associated with splenomegaly, and laparoscopic splenectomy may have a beneficial effect on PHG, at least for a short time.
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Authors | Go Anegawa, Hirofumi Kawanaka, Hideo Uehara, Tomohiko Akahoshi, Kozo Konishi, Daisuke Yoshida, Nao Kinjo, Naotaka Hashimoto, Morimasa Tomikawa, Makoto Hashizume, Yoshihiko Maehara |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 24
Issue 9
Pg. 1554-8
(Sep 2009)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 19743999
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Endoscopy, Gastrointestinal
- Female
- Humans
- Hypertension, Portal
(etiology, pathology, surgery)
- Laparoscopes
- Liver Cirrhosis
(complications, pathology, surgery)
- Liver Function Tests
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Prevalence
- Prospective Studies
- Risk Assessment
- Severity of Illness Index
- Splenectomy
(methods)
- Splenomegaly
(etiology, pathology, surgery)
- Stomach Diseases
(etiology, pathology, surgery)
- Time Factors
- Treatment Outcome
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