ATP synthase inhibition of Mycobacterium avium is not bactericidal.

Abstract

The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.

• Authors: Nacer Lounis, Tom Gevers, Joke Van den Berg, Luc Vranckx, Koen Andries
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 11 Pg. 4927-9 (Nov 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19738016 (Publication Type: Journal Article)

Chemical References

• Antitubercular Agents
• Diarylquinolines
• Enzyme Inhibitors
• Quinolines
• bedaquiline

Topics

• Animals
• Antitubercular Agents (pharmacology)
• Diarylquinolines
• Enzyme Inhibitors (pharmacology)
• Female
• Mice
• Mice, Inbred C57BL
• Microbial Sensitivity Tests
• Mycobacterium avium (drug effects)
• Quinolines (pharmacokinetics, pharmacology)