Abstract | CONTEXT: A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). OBJECTIVE: To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression. DESIGN: Two prospective longitudinal cohort studies. SETTING: England and New Zealand. PARTICIPANTS: Participants in the first sample were women in the E-Risk Study (N = 1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and women in the Dunedin Study (N = 1037), followed up to age 32 years with 96% retention. Main Outcome Measure Research diagnoses of past-year and recurrent major depressive disorder. RESULTS: In the E-Risk Study, the TAT haplotype was associated with a significant protective effect. In this effect, women who reported childhood maltreatment on the CTQ were protected against depression. In the Dunedin Study, which used a different type of measure of maltreatment, this finding was not replicated. CONCLUSIONS: A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences.
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Authors | Guilherme Polanczyk, Avshalom Caspi, Benjamin Williams, Thomas S Price, Andrea Danese, Karen Sugden, Rudolf Uher, Richie Poulton, Terrie E Moffitt |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 66
Issue 9
Pg. 978-85
(Sep 2009)
ISSN: 1538-3636 [Electronic] United States |
PMID | 19736354
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Corticotropin-Releasing Hormone
- CRF receptor type 1
- Corticotropin-Releasing Hormone
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Topics |
- Adult
- Child
- Child Abuse
(psychology, statistics & numerical data)
- Child Abuse, Sexual
(psychology, statistics & numerical data)
- Child, Preschool
- Corticotropin-Releasing Hormone
(genetics)
- Depressive Disorder
(diagnosis, genetics, prevention & control)
- Female
- Genetic Variation
(genetics)
- Genotype
- Haplotypes
(genetics)
- Humans
- Life Change Events
- Male
- Middle Aged
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Psychiatric Status Rating Scales
- Receptors, Corticotropin-Releasing Hormone
(genetics)
- Surveys and Questionnaires
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