Effect of a dentifrice containing the peptide of streptococcal antigen I/II on the adherence of mutans streptococcus.

Abstract

OBJECTIVE:

Antigen I/II of mutans streptococcus (MS) is a surface protein, which binds to salivary receptors. The objective of this study was to study the effect of a peptide corresponding to residues 1025-1044 of antigen I/II and a dentifrice containing peptide on the adherence of MS.

METHODS:

The peptide was synthesized and included into dentifrice. Anti-adherence experiments of the peptide and a dentifrice containing it were processed in vitro and in vivo.

RESULTS:

The results showed that the adherence of MS to hydroxyapatite was inhibited by synthetic antigen I/II peptide and also by a dentifrice containing the peptide in vitro. The numbers of MS in plaque from subjects treated with dentifrices containing the peptide for 1 month was significantly reduced compared to baseline (log 3.11+/-0.80 vs log 4.09+/-0.90, P<0.01), whereas the control group showed no reduction.

CONCLUSION:

The adherence of MS to hydroxyapatite was inhibited by both a synthetic peptide and a dentifrice containing the peptide. The peptide dentifrice produced a significant reduction of MS in dental plaque in vivo.

• Authors: Ming-Yu Li, Jun Wang, Guang-Yun Lai
• Journal: Archives of oral biology (Arch Oral Biol) Vol. 54 Issue 11 Pg. 1068-73 (Nov 2009) ISSN: 1879-1506 [Electronic] England
• PMID: 19735908 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Bacterial
• Dentifrices
• Peptide Fragments
• Durapatite

Topics

• Adult
• Amino Acid Sequence
• Antigens, Bacterial (pharmacology)
• Bacterial Adhesion (drug effects)
• Cross-Over Studies
• Dental Pellicle (microbiology)
• Dental Plaque (drug therapy, microbiology)
• Dentifrices (chemistry, pharmacology)
• Double-Blind Method
• Durapatite
• Female
• Humans
• Male
• Peptide Fragments (chemical synthesis, pharmacology)
• Streptococcus mutans (drug effects)
• Young Adult