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Time-course of 5-HT(6) receptor mRNA expression during memory consolidation and amnesia.

Abstract
Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor(6) (5-HT(6)) improve memory and reverse amnesia although the mechanisms involved are poorly understood. Hence, in this paper RT-PCR was used to evaluate changes in mRNA expression of 5-HT(6) receptor in trained and untrained rats treated with the 5-HT(6) receptor antagonist SB-399885 and amnesic drugs scopolamine or dizocilpine. Changes in mRNA expression of 5-HT(6) receptor were investigated at different times in prefrontal cortex, hippocampus and striatum. Data indicated that memory in the Pavlovian/instrumental autoshaping task was a progressive process associated to reduced mRNA expression of 5-HT(6) receptor in the three structures examined. SB-399885 improved long-term memory at 48h, while the muscarinic receptor antagonist scopolamine or the non-competitive NMDA receptor antagonist dizocilpine impaired it at 24h. Autoshaping training and treatment with SB-399885 increased 5-HT(6) receptor mRNA expression in (maximum increase) prefrontal cortex and striatum, 24 or 48h. The scopolamine-induced amnesia suppressed 5-HT(6) receptor mRNA expression while the dizocilpine-induced amnesia did not modify 5-HT(6) receptor mRNA expression. SB-399885 and scopolamine or dizocilpine were able to reestablish memory and 5-HT(6) receptor mRNA expression. These data confirmed previous memory evidence and of more interest is the observation that training, SB-399885 and amnesic drugs modulated 5-HT(6) receptor mRNA expression in prefrontal cortex, hippocampus and striatum. Further investigation in different memory tasks, times and amnesia models together with more complex control groups might provide further clues.
AuthorsA Huerta-Rivas, G Pérez-García, C González-Espinosa, A Meneses
JournalNeurobiology of learning and memory (Neurobiol Learn Mem) Vol. 93 Issue 1 Pg. 99-110 (Jan 2010) ISSN: 1095-9564 [Electronic] United States
PMID19733250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2009 Elsevier Inc. All rights reserved.
Chemical References
  • Piperazines
  • Psychotropic Drugs
  • RNA, Messenger
  • Receptors, Serotonin
  • SB 399885
  • Serotonin Antagonists
  • Sulfonamides
  • serotonin 6 receptor
  • Dizocilpine Maleate
  • Scopolamine
Topics
  • Amnesia (chemically induced, metabolism)
  • Animals
  • Brain (drug effects, metabolism)
  • Conditioning, Classical (drug effects, physiology)
  • Corpus Striatum (drug effects, metabolism)
  • Dizocilpine Maleate (pharmacology)
  • Hippocampus (drug effects, metabolism)
  • Male
  • Memory (drug effects, physiology)
  • Piperazines (pharmacology)
  • Prefrontal Cortex (drug effects, metabolism)
  • Psychotropic Drugs (pharmacology)
  • RNA, Messenger (metabolism)
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin (metabolism)
  • Scopolamine (pharmacology)
  • Serotonin Antagonists (pharmacology)
  • Sulfonamides (pharmacology)
  • Time Factors

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