Abstract | OBJECTIVE: METHODS: Thirty-eight patients with confirmed CPA were compared with 18 healthy subjects as well as 48 control patients suffering from aldosterone-producing adenomas (n=13), pheochromocytomas (n=16), or nonfunctioning adenomas (n=19). Sampling of saliva and serum was performed at 2300 and at 0800 h following low-dose dexamethasone suppression. Receiver operating characteristics analysis was used to calculate thresholds with at least 95% sensitivity for CPA. RESULTS: Regarding the cutoffs for late-night cortisol, SaC (4.8 nmol/l, sensitivity 97%, specificity 69%) was slightly more specific than SeC (115 nmol/l, sensitivity 97%, specificity 63%). In contrast, the cutoff for dexamethasone-suppressed SaC (3.7 nmol/l, sensitivity 97%, specificity 83%) was slightly less specific than SeC (94 nmol/l, sensitivity 97%, specificity 88%). However, the latter cutoffs demonstrated greater specificity when compared with the cutoffs for late-night cortisol. CONCLUSION:
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Authors | Timo Deutschbein, Nicole Unger, Jakob Hinrichs, Martin K Walz, Klaus Mann, Stephan Petersenn |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 161
Issue 5
Pg. 747-53
(Nov 2009)
ISSN: 1479-683X [Electronic] England |
PMID | 19726566
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dexamethasone
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Adenoma
(diagnosis, metabolism)
- Adrenal Gland Neoplasms
(diagnosis, metabolism)
- Adrenocorticotropic Hormone
(blood)
- Adult
- Cushing Syndrome
(diagnosis, physiopathology)
- Dexamethasone
(administration & dosage)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hydrocortisone
(blood, metabolism)
- Male
- Middle Aged
- Prospective Studies
- ROC Curve
- Saliva
(drug effects, metabolism)
- Sensitivity and Specificity
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