BATF: bringing (in) another Th17-regulating factor.

Abstract

T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining RORalpha and RORgammat expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.

• Authors: Gustavo J Martinez, Chen Dong
• Journal: Journal of molecular cell biology (J Mol Cell Biol) Vol. 1 Issue 2 Pg. 66-8 (Dec 2009) ISSN: 1759-4685 [Electronic] United States
• PMID: 19726487 (Publication Type: Journal Article)

Chemical References

• Basic-Leucine Zipper Transcription Factors
• Batf protein, mouse
• Cytokines
• Orphan Nuclear Receptors

Topics

• Animals
• Basic-Leucine Zipper Transcription Factors (deficiency, genetics, metabolism)
• Cell Differentiation
• Cytokines (metabolism)
• Lymphocyte Activation (immunology)
• Mice
• Orphan Nuclear Receptors (metabolism)
• T-Lymphocytes, Helper-Inducer (cytology, metabolism)