Abstract | BACKGROUND: METHODS: This prospective, open-label, non-randomized trial included 82 women with pain symptoms caused by rectovaginal endometriosis. Patients received either a combination of letrozole and norethisterone acetate (group L) or norethisterone acetate alone (group N) for 6 months. Changes in pain symptoms during treatment and in the 12 months of follow-up were evaluated. Side effects of each treatment protocol were recorded. RESULTS: Intensity of chronic pelvic pain and deep dyspareunia significantly decreased during treatment (P < 0.001 versus baseline by 3 months) in both study groups. At both 3- and 6-month assessment, the intensity of chronic pelvic pain (P < 0.001, P = 0.002, respectively) and deep dyspareunia (P < 0.001, P = 0.005, respectively) was significantly lower in group L than group N. At completion of treatment, 63.4% of women in group N were satisfied with treatment compared with 56.1% in group L (P = 0.49). Pain symptoms recurred after the completion of treatment; at 6-month follow-up no difference was observed in the intensity of pain symptoms between the groups. Adverse effects were more frequent in group L than in group N (P = 0.02). CONCLUSIONS:
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Authors | S Ferrero, G Camerini, R Seracchioli, N Ragni, P L Venturini, V Remorgida |
Journal | Human reproduction (Oxford, England)
(Hum Reprod)
Vol. 24
Issue 12
Pg. 3033-41
(Dec 2009)
ISSN: 1460-2350 [Electronic] England |
PMID | 19726448
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Analgesics, Non-Narcotic
- Aromatase Inhibitors
- Nitriles
- Triazoles
- Letrozole
- Norethindrone Acetate
- Norethindrone
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Topics |
- Adult
- Analgesics, Non-Narcotic
(adverse effects, economics, therapeutic use)
- Aromatase Inhibitors
(adverse effects, economics, therapeutic use)
- Drug Therapy, Combination
(adverse effects, economics)
- Dysmenorrhea
(drug therapy, etiology)
- Dyspareunia
(drug therapy, etiology)
- Endometriosis
(complications, surgery)
- Female
- Humans
- Letrozole
- Nitriles
(adverse effects, economics, therapeutic use)
- Norethindrone
(adverse effects, analogs & derivatives, therapeutic use)
- Norethindrone Acetate
- Pain Measurement
- Patient Satisfaction
(statistics & numerical data)
- Pelvic Pain
(drug therapy, etiology)
- Prospective Studies
- Time Factors
- Treatment Outcome
- Triazoles
(adverse effects, economics, therapeutic use)
- Young Adult
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