Abstract | OBJECTIVE: METHODS: Twenty dogs were selected to prepare the intracranial hemorrhage model, which were randomly divided into 6, 12, 18 and 24 hour groups, respectively. The animals in each group underwent a minimally invasive surgery to evacuate the cerebral hematoma after the models were prepared. Before and after procedures, Purdy score, MEP and thrombin in hematoma region were determined and compared. RESULTS: Significant decreases in Purdy score, latency of MEP and thrombin expression were observed in 6 and 12 hour groups as compared with the 18 and 24 hour groups (p<0.01). DISCUSSION: In the present experiment, we established a dog model of intracranial hemorrhage, which was minimally invasive, easy to operate, highly repeated, simulating the pathological and physiological changes of clinical hypertensive intracranial hemorrhage. Both the latency of MEP and the expression of thrombin decreased after evacuation of intracranial hematoma in early stages by minimally invasive procedures, indicating that minimally invasive procedures for cerebral hematoma in ultra-early and early stages might be more effective to limit brain injury and decrease the latency of MEP and thrombin expression.
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Authors | Guofeng Wu, Weibin Zhong |
Journal | Neurological research
(Neurol Res)
Vol. 32
Issue 2
Pg. 127-33
(Mar 2010)
ISSN: 1743-1328 [Electronic] England |
PMID | 19726015
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Animals
- Disease Models, Animal
- Dogs
- Evoked Potentials, Motor
(physiology)
- Female
- Hematoma, Subdural, Intracranial
(metabolism, physiopathology, surgery)
- Intracranial Hemorrhages
(metabolism, physiopathology, surgery)
- Male
- Minimally Invasive Surgical Procedures
(methods)
- Thrombin
(biosynthesis)
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