Exchange transfusion of least incompatible blood for severe hemolytic disease of the newborn due to anti-Rh17.

Abstract

HDN attributed to the rare Rh variants has become more and more significant caused by anti-D, but the compatible blood is usually very difficult to obtain when exchange transfusion is required. We treated a 10-hour neonate of O, D + C + c - E - e+ blood group with severe HDN due to anti-Rh17 with least incompatible blood typed O, D + C - c + E + e-. The neonatal hemolysis was relieved obviously and bilirubin was reduced gradually after exchange transfusion. The infant was discharged in good health 13 days after birth with 135.0 g/L, 28.0 micromol/L and 10.7 micromol/L of Hb, total bilirubin and direct bilirubin, respectively. No sequelae were observed in a three-year follow-up. The result suggesting that the least incompatible blood is an alternative choice for exchange transfusion in severe HDN due to anti-Rh17 in case that Rh17 antigen-negative blood is unavailable.

• Authors: Bi-juan Li, Yuan-jun Jiang, Fen Yuan, Hong-xing Ye
• Journal: Transfusion medicine (Oxford, England) (Transfus Med) Vol. 20 Issue 1 Pg. 66-9 (Feb 2010) ISSN: 1365-3148 [Electronic] England
• PMID: 19725902 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous
• Immunosuppressive Agents
• Isoantibodies
• RHO(D) antibody
• Rh-Hr Blood-Group System
• Rho(D) Immune Globulin
• Rho(D) antigen
• Methylprednisolone

Topics

• Adult
• Blood Component Transfusion (methods)
• Blood Group Incompatibility (drug therapy, immunology)
• Blood Grouping and Crossmatching
• Erythrocyte Transfusion
• Female
• Humans
• Hydrops Fetalis (immunology, therapy)
• Hyperbilirubinemia, Neonatal (etiology, radiotherapy, therapy)
• Immunoglobulins, Intravenous (therapeutic use)
• Immunosuppressive Agents (therapeutic use)
• Infant, Newborn
• Isoantibodies (immunology)
• Leukocyte Reduction Procedures
• Male
• Methylprednisolone (therapeutic use)
• Plasma
• Pregnancy
• Rh Isoimmunization
• Rh-Hr Blood-Group System (immunology)
• Rho(D) Immune Globulin
• Ultraviolet Therapy
• Young Adult