Spironolactone and altizide in systemic hypertension: ambulatory multicenter study.

Abstract

A multicenter study was performed in 919 hypertensive patients, 780 of whom could be evaluated. Patients in group I (n = 482) were treated with Aldactazine alone (altizide + spironolactone, 2 tablets per day). The other 298 patients (group II) were treated with 1 or 2 tablets per day of Aldactazine plus a conventional antihypertensive agent, e.g., a beta blocker, alpha-methyldopa or clonidine. After 45 days of treatment with Aldactazine alone, mean systolic and diastolic blood pressure (BP) decreased by 15 and 14%, respectively, vs baseline values. The addition of the other antihypertensive agent decreased BP further; however, the best results were obtained with the combination of Aldactazine and clonidine. With this combination, systolic and diastolic BP decreased by 16.6 and 18%, respectively, vs baseline. In terms of adverse effects, a few cases of gastrointestinal disturbances and orthostatic hypotension were reported.

• Authors: J Sternon
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 65 Issue 23 Pg. 24K-27K (Jun 19 1990) ISSN: 0002-9149 [Print] United States
• PMID: 1972313 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Adrenergic beta-Antagonists
• Benzothiadiazines
• Diuretics
• Drug Combinations
• Sodium Chloride Symporter Inhibitors
• Sulfonamides
• Spironolactone
• Methyldopa
• spironolactone, althiazide drug combination
• Clonidine

Topics

• Adrenergic beta-Antagonists (administration & dosage, therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Benzothiadiazines
• Clonidine (administration & dosage, therapeutic use)
• Diuretics
• Drug Combinations (administration & dosage, adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Male
• Methyldopa (administration & dosage, therapeutic use)
• Middle Aged
• Multicenter Studies as Topic
• Sodium Chloride Symporter Inhibitors (administration & dosage, adverse effects, therapeutic use)
• Spironolactone (administration & dosage, adverse effects, therapeutic use)
• Sulfonamides (administration & dosage, adverse effects, therapeutic use)