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Treatment of lymphoma with adoptively transferred T cells.

AbstractBACKGROUND:
Chemotherapy-resistant lymphomas can be cured with allogeneic hematopoietic cell transplantation, demonstrating the susceptibility of these tumors to T cell mediated immune responses. However, high rates of transplant-related morbidity and mortality limit this approach. Efforts have, therefore, been made to develop alternative T cell based therapies, and there is growing evidence that adoptive therapy with T cells targeted to lymphoma-associated antigens may be a safe and effective new method for treating this group of diseases.
OBJECTIVE/METHODS:
We review publications on adoptive therapy with ex vivo expanded T cells targeting viral antigens, as well as genetically modified autologous T cells, as strategies for the treatment of lymphoma, with the goal of providing an overview of these approaches.
RESULTS/CONCLUSIONS:
Epstein-Barr virus specific T cell therapy is an effective and safe method of treating Epstein-Barr virus associated lymphomas; however, most lymphoma subtypes do not express EBV antigens. For these diseases, adoptive immunotherapy with genetically modified T cells expressing chimeric T cell receptors targeting lymphoma-associated antigens such as CD19 and CD20 appears to be a promising alternative. Recent innovations including enhanced co-stimulation, exogenous cytokine administration and use of memory T cells promise to overcome many of the limitations and pitfalls initially encountered with this approach.
AuthorsBrian G Till, Oliver W Press
JournalExpert opinion on biological therapy (Expert Opin Biol Ther) Vol. 9 Issue 11 Pg. 1407-25 (Nov 2009) ISSN: 1744-7682 [Electronic] England
PMID19723016 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Receptors, Antigen, T-Cell
Topics
  • Adoptive Transfer
  • Herpesvirus 4, Human (immunology)
  • Humans
  • Lymphoma (therapy, virology)
  • Receptors, Antigen, T-Cell (immunology)

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