Unexpected preferential dehydration of artemisinin in ionic liquids.

Abstract

Thermodynamic measurements (at 298 K) reveal that a crucial step in the extraction process of the key antimalarial drug artemisinin by ionic liquids (ILs), namely, precipitation through the addition of water, is driven by artemisinin dehydration due to the differences in the water's interaction with the bulk ILs, rather than with the artemisinin itself.

• Authors: Marc W Sanders, Lawrence Wright, Lauren Tate, Gayle Fairless, Lorna Crowhurst, Neil C Bruce, Adam J Walker, Guy A Hembury, Seishi Shimizu
• Journal: The journal of physical chemistry. A (J Phys Chem A) Vol. 113 Issue 38 Pg. 10143-5 (Sep 24 2009) ISSN: 1520-5215 [Electronic] United States
• PMID: 19722599 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Artemisinins
• Ionic Liquids
• Water
• artemisinin

Topics

• Artemisinins (chemistry)
• Dehydration
• Ionic Liquids (chemistry)
• Thermodynamics
• Water (chemistry)