Abstract | AIMS: DESIGN: We compared early life experiences in 2061 individuals with a lifetime diagnosis of alcohol, cocaine, or opioid dependence and 449 controls. MEASUREMENTS: FINDINGS: Childhood abuse or exposure to violent crime was positively related to the number of lifetime mood and anxiety disorders and to SD risk. Mood and anxiety disorders had their first onset a mean of nearly 3 years before the first SD diagnosis and partially mediated the effect of ACEs on SD risk. CONCLUSION:
ACEs appear to contribute additively to the risk of SD, with mood and anxiety disorders in the causal path for a portion of this risk. The identification and effective treatment of mood and anxiety disorders associated with ACEs could reduce the risk of developing SD.
|
Authors | Kara R Douglas, Grace Chan, Joel Gelernter, Albert J Arias, Raymond F Anton, Roger D Weiss, Kathleen Brady, James Poling, Lindsay Farrer, Henry R Kranzler |
Journal | Addictive behaviors
(Addict Behav)
Vol. 35
Issue 1
Pg. 7-13
(Jan 2010)
ISSN: 1873-6327 [Electronic] England |
PMID | 19720467
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Topics |
- Adult
- Anxiety Disorders
(epidemiology, psychology)
- Child
- Child Abuse
(statistics & numerical data)
- Domestic Violence
(statistics & numerical data)
- Family Relations
- Female
- Humans
- Life Change Events
- Male
- Middle Aged
- Mood Disorders
(epidemiology, psychology)
- Risk Factors
- Substance-Related Disorders
(epidemiology, psychology)
|