Abstract |
To evaluate the efficacy of ceftazidime monotherapy in the empirical treatment of febrile neutropenic patients, a randomized trial was performed of ceftazidime (C) vs. ceftazidime and gentamicin (C + G) with the addition of teicoplanin (T) for those patients with a long intravenous line-associated infection. Success without modification at the end of treatment was seen in 32.7% (C), 28.3% (C + G), 52.4% (C + T) and 65.2% (C + G + T). Monotherapy with ceftazidime is as effective as when used in combination with an aminoglycoside in neutropenia.
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Authors | S E Kinsey, S J Machin, A H Goldstone |
Journal | The Journal of hospital infection
(J Hosp Infect)
Vol. 15 Suppl A
Pg. 49-53
(Apr 1990)
ISSN: 0195-6701 [Print] England |
PMID | 1971645
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Gentamicins
- Glycopeptides
- Teicoplanin
- Ceftazidime
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Topics |
- Agranulocytosis
(complications)
- Anti-Bacterial Agents
(therapeutic use)
- Cause of Death
- Ceftazidime
(therapeutic use)
- Drug Therapy, Combination
- Female
- Fever
(drug therapy, etiology, mortality)
- Gentamicins
(therapeutic use)
- Glycopeptides
(therapeutic use)
- Humans
- Male
- Neutropenia
(complications)
- Randomized Controlled Trials as Topic
- Teicoplanin
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