Abstract |
Several studies have shown that the anti-inflammatory effect of Pioglitazone extends beyond the cardiovascular system. This study examines the anti-inflammatory effect of Pioglitazone in comparison to reference drugs ( Dexamethasone and Indomethacin) in the mouse model of pleurisy induced by carrageenan which is characterized by two distinct phases (4 and 48 h) of inflammation. Pioglitazone (20 and 50 mg/kg, i.p., 0.5 h before pleurisy) inhibited both neutrophil (4 h) and mononuclears (48 h) influxes (P<0.01), but not exudation (P>0.05). While one dose of Pioglitazone was effective in inhibiting inflammation at 4 h, additional doses (10 or 20 mg/kg, i.p., 0.5 h before pleurisy induction followed by either a second dose at 24 h after the first one or two further doses at 12 h of time interval after the first one) were necessary to elicit inhibition of the second (48 h) inflammation phase. These effects were associated with a marked decrease in adenosine-deaminase (ADA) activity, tumor necrosis factor-alpha ( TNF-alpha) and interleukin 1-beta (IL-1beta) levels (P<0.01). Myeloperoxidade (MPO) activity was inhibited only at 4 h (P<0.05). By contrast, reference drugs were able to inhibit all the studied inflammatory parameters (P<0.05). These results demonstrated an interesting anti-inflammatory property of this thiazolidinedione class and strengthen prior evidence that PPAR pathways constitute another important route of inflammatory process inhibition of this pleurisy model.
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Authors | Tânia Silvia Fröde, Ziliani da Silva Buss, Gustavo Oliveira dos Reis, Yara Santos Medeiros |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 9
Issue 12
Pg. 1394-400
(Nov 2009)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 19716439
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Interleukin-1beta
- Thiazolidinediones
- Tumor Necrosis Factor-alpha
- Carrageenan
- Peroxidase
- Adenosine Deaminase
- Pioglitazone
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Topics |
- Adenosine Deaminase
(genetics, immunology, metabolism)
- Animals
- Anti-Inflammatory Agents
(administration & dosage)
- Carrageenan
(administration & dosage)
- Cell Movement
(drug effects, immunology)
- Immunosuppression Therapy
- Interleukin-1beta
(genetics, immunology, metabolism)
- Leukocytes, Mononuclear
(drug effects, pathology)
- Mice
- Neutrophils
(drug effects, pathology)
- Peroxidase
(genetics, immunology, metabolism)
- Pioglitazone
- Pleurisy
(chemically induced, drug therapy, enzymology, immunology, pathology)
- Thiazolidinediones
(administration & dosage)
- Tumor Necrosis Factor-alpha
(genetics, immunology, metabolism)
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