Sclerotherapy of branchial cleft cysts using OK-432.

Abstract

OBJECTIVES:

OK-432 has been widely used to treat lymphangioma and ranula; however, there are few studies for its use in treatment of branchial cleft cyst (BCC). We conducted this study to evaluate the effectiveness of sclerotherapy using OK-432 in treatment of BCC.

STUDY DESIGN AND SETTING:

Case series with planned data collection.

SUBJECTS AND METHODS:

From 2004 to 2007, we treated 23 patients with BCC using OK-432 sclerotherapy. Of these 23 patients, 18 had unilocular cysts and five had multilocular cysts. The sizes of the BCCs were measured and compared before and after treatment.

RESULTS:

Of the 23 cases, 14 (60.8%) showed complete regression; all of these were unilocular cysts. Of the remaining individuals with unilocular cysts, only one patient failed to show any response. This individual subsequently underwent surgical excision. A total of five patients with multilocular cysts showed no or partial response and subsequently underwent surgical excision. Minor adverse effects including fever and local pain were reported by 13 (56.5%) patients.

CONCLUSION:

These results suggest that sclerotherapy using OK-432 is an effective and safe treatment modality for BCC, especially for unilocular cysts. Sclerosing of unilocular BCC with OK-432 should therefore be considered before surgical excision.

• Authors: Myung-Gu Kim, No-Hee Lee, Jae-Ho Ban, Kyung-Chul Lee, Sung-Min Jin, Sang-Hyuk Lee
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 141 Issue 3 Pg. 329-34 (Sep 2009) ISSN: 0194-5998 [Print] England
• PMID: 19716008 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Picibanil

Topics

• Adolescent
• Adult
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Biopsy, Fine-Needle
• Branchioma (diagnosis, therapy)
• Diagnosis, Differential
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Head and Neck Neoplasms (diagnosis, drug therapy)
• Humans
• Injections, Intralymphatic
• Male
• Middle Aged
• Picibanil (administration & dosage, therapeutic use)
• Prospective Studies
• Sclerotherapy (methods)
• Tomography, X-Ray Computed
• Treatment Outcome
• Young Adult