Abstract |
In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.
|
Authors | L Colonna, F Cozzi, F Del Citerna, A Di Benedetto, O De Divitiis, F Furlanello, F Milazzotto, M Pittalis, A Taccola |
Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
1990 Jan-Feb
Vol. 38
Issue 1-2
Pg. 45-9
ISSN: 0026-4725 [Print] Italy |
Vernacular Title | Studio policentrico sull'efficacia e tollerabilità del clotiazepam in cardiologia. |
PMID | 1971433
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
|
Chemical References |
|
Topics |
- Adolescent
- Adult
- Aged
- Anxiety
(complications, drug therapy)
- Azepines
(administration & dosage, therapeutic use)
- Cardiovascular Diseases
(psychology)
- Drug Evaluation
- Female
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Psychiatric Status Rating Scales
|