Abstract | BACKGROUND: Renal tubule cell apoptosis plays a pivotal role in cisplatin-induced nephrotoxicity. alpha-Lipoic acid (LA), a thiol antioxidant, is well known to be cytoprotective in various cell death models through its involvement in the death receptor apoptosis pathway. However, we hypothesized that LA would attenuate cisplatin-induced nephrotoxicity through inhibition of mitochondrial bax translocation in rats. METHODS AND MATERIALS: RESULTS: LA pretreatment significantly decreased both BUN and serum creatinine. Morphologically, both tubular necrosis and apoptosis of tubular cells were decreased significantly with LA pretreatment. LA attenuated the translocation of mitochondrial bax, reduced the release of cytochrome c, and decreased the expression of caspase-3 and caspase-9 serially in cisplatin nephrotoxicity. CONCLUSION: We demonstrated that LA attenuates cisplatin-induced renal tubular damages by inhibition of mitochondrial bax translocation in vivo.
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Authors | Young Mo Lee, So Yon Bae, Nam Hee Won, Heui Jung Pyo, Young Joo Kwon |
Journal | Nephron. Experimental nephrology
(Nephron Exp Nephrol)
Vol. 113
Issue 4
Pg. e104-12
( 2009)
ISSN: 1660-2129 [Electronic] Switzerland |
PMID | 19713707
(Publication Type: Journal Article)
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Copyright | 2009 S. Karger AG, Basel. |
Chemical References |
- Antioxidants
- bcl-2-Associated X Protein
- Thioctic Acid
- Sodium
- Creatinine
- Caspase 3
- Caspase 9
- Cisplatin
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Apoptosis
(drug effects)
- Blood Urea Nitrogen
- Caspase 3
(metabolism)
- Caspase 9
(metabolism)
- Cisplatin
- Creatinine
(blood)
- Disease Models, Animal
- Kidney Tubules
(drug effects, metabolism, pathology)
- Male
- Mitochondria
(drug effects, metabolism)
- Necrosis
- Nephritis, Interstitial
(chemically induced, metabolism, prevention & control)
- Rats
- Rats, Sprague-Dawley
- Sodium
(urine)
- Thioctic Acid
(pharmacology)
- Translocation, Genetic
(drug effects)
- bcl-2-Associated X Protein
(genetics, metabolism)
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