Abstract |
Manganese superoxide dismutase (MnSOD) acts as an antioxidant and protects cells from the harmful effects of reactive oxygen species. We investigated the relationship between the MnSOD Ala-9Val polymorphism and breast cancer. Genotypes of 250 cases and 330 controls were determined by use of PCR-RFLP. Compared with the MnSOD Val/Val genotype, the MnSOD Val/Ala or MnSOD Ala/Ala genotype was not significantly associated with the overall risk for breast cancer. The risk increased in women with MnSOD Ala allele-containing genotypes as well as higher level of education ( Ala/Ala: OR, 6.00; 95% CI, 1.02-35.33), BMI >or= 25 kg/m(2) (Val/Ala: OR, 1.74; 95% CI, 1.10-2.76), late age at first pregnancy (Val/Ala: OR, 1.52; 95% CI, 1.01-2.42), and premenopausal status (Val/Ala: OR, 1.78; 95% CI, 1.03-3.10). In conclusion, the MnSOD Ala-9Val polymorphism may contribute to an increased risk for breast cancer development, particularly in the presence of a higher level of education, high BMI, late age at first pregnancy, and premenopausal status.
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Authors | N Eras-Erdogan, E Akbas, H Senli, S Kul, T Colak |
Journal | Mutation research
(Mutat Res)
2009 Nov-Dec
Vol. 680
Issue 1-2
Pg. 7-11
ISSN: 0027-5107 [Print] Netherlands |
PMID | 19712751
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Breast Neoplasms
(enzymology, genetics, pathology)
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(epidemiology)
- Humans
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Risk Factors
- Superoxide Dismutase
(genetics, metabolism)
- Turkey
(epidemiology)
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