Abstract |
The BREATHE-5 study demonstrated that bosentan, an oral endothelin receptor antagonist, provides clinical benefits in patients with Eisenmenger's syndrome. As a result, the European Medicines Agency (EMEA) approved its use for this indication. However, follow-up in that study was limited to 16 weeks and patients with complex congenital heart disease were excluded. We assessed the effect of long-term bosentan treatment in 10 patients with complex congenital heart disease and Eisenmenger's syndrome. In the mean clinical follow-up period of 25 months, all patients reached the target dose without developing side effects and without experiencing a change in arterial oxygen consumption at either rest or maximal exercise. Moreover, there were significant changes in clinical parameters: NYHA functional class improved from 3.3+/-0.7 to 2.5+/-0.9 (P=.002) and the 6-minute walk distance increased from 266+/-161 m to 347+/-133 m (P=.015).
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Authors | Eva Díaz-Caraballo, Ana E González-García, Margarita Reñones, Angel Sánchez-Recalde, Francisco García-Río, José M Oliver-Ruiz |
Journal | Revista espanola de cardiologia
(Rev Esp Cardiol)
Vol. 62
Issue 9
Pg. 1046-9
(Sep 2009)
ISSN: 1579-2242 [Electronic] Spain |
PMID | 19712626
(Publication Type: Journal Article)
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Chemical References |
- Endothelin Receptor Antagonists
- Sulfonamides
- Bosentan
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Topics |
- Adult
- Bosentan
- Eisenmenger Complex
(complications, drug therapy)
- Endothelin Receptor Antagonists
- Female
- Heart Diseases
(complications, congenital, drug therapy)
- Humans
- Male
- Sulfonamides
(therapeutic use)
- Time Factors
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