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Novel biomarkers of acute kidney toxicity.

Abstract
Novel biomarkers of kidney toxicity are powerful tools not only with respect to their clinical applications but also because of their impact on drug development. These biomarkers can influence the assessment of efficacy of new drugs for kidney diseases as well as the risk management for new drugs. The science behind these novel biomarkers reflects the evolution over the past decade of genomic and proteomic platforms that have transformed the discovery and development of new biomarkers for preclinical and clinical applications in drug development. Several of these biomarkers are in use as transcriptomic biomarkers in animal models as well as translational proteomic biomarkers in animal models and in humans. Their ability to detect kidney damage earlier than is possible with currently accessible biomarkers is being given qualification through regulatory biomarker-qualification programs, which will help establish consensus for their widespread use.
AuthorsF M Goodsaid, M Blank, F Dieterle, P Harlow, E Hausner, F Sistare, A Thompson, J Vonderscher
JournalClinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 86 Issue 5 Pg. 490-6 (Nov 2009) ISSN: 1532-6535 [Electronic] United States
PMID19710639 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
Topics
  • Acute Kidney Injury (chemically induced, diagnosis, physiopathology)
  • Animals
  • Biomarkers (analysis, metabolism)
  • Drug Design
  • Drug Evaluation, Preclinical
  • Drug-Related Side Effects and Adverse Reactions
  • Genomics (trends)
  • Humans
  • Models, Animal
  • Proteomics (trends)
  • Risk Management (methods)

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