Abstract | BACKGROUND: OBJECTIVE: The objective was to determine whether GST genotypes modify the association between dietary vitamin C and serum ascorbic acid. DESIGN: Nonsmoking men and women (n = 905) between 20 and 29 y of age were participants in the Toronto Nutrigenomics and Health Study. Overnight fasting blood samples were collected to determine serum ascorbic acid concentrations by HPLC and to genotype for deletion polymorphisms in GSTM1 and GSTT1 and an Ile105Val substitution in GSTP1. A 196-item food-frequency questionnaire was used to estimate vitamin C intake. RESULTS: A gene-diet interaction on serum ascorbic acid was observed for GSTM1 (P = 0.04) and GSTT1 (P = 0.01) but not for GSTP1 (P = 0.83). The odds ratio (95% CI) for serum ascorbic acid deficiency (<11 micromol/L) was 3.20 (1.88, 5.44) for subjects who did not meet the Recommended Dietary Allowance of vitamin C compared with those who did. The corresponding odds ratios (95% CIs) were 2.17 (1.10, 4.28) and 12.28 (4.26, 33.42), respectively, for individuals with the GSTT1*1/*1 +*1/*0 (functional) and GSTT1*0/*0 (null) genotypes and 2.29 (0.96, 5.45) and 4.03 (2.01, 8.09), respectively, for the GSTM1*1/*1+GSTM1*1/*0 and GSTM1*0/*0 genotypes. CONCLUSIONS:
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Authors | Leah E Cahill, Bénédicte Fontaine-Bisson, Ahmed El-Sohemy |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 90
Issue 5
Pg. 1411-7
(Nov 2009)
ISSN: 1938-3207 [Electronic] United States |
PMID | 19710200
(Publication Type: Journal Article)
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Chemical References |
- glutathione S-transferase T1
- Glutathione Transferase
- glutathione S-transferase M1
- Ascorbic Acid
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Topics |
- Adult
- Ascorbic Acid
(blood)
- Ascorbic Acid Deficiency
(prevention & control)
- Cross-Sectional Studies
- Exercise
- Female
- Genetic Variation
- Genotype
- Glutathione Transferase
(genetics)
- Humans
- Male
- Ontario
- Young Adult
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