HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Highlights and hotspots of protein glycation in end-stage renal disease.

Abstract
Analysis of tissues, plasma, urine, other body fluids, and dialysate for glycation adducts has revealed the presence of two major forms: glycation adduct residues of proteins and related glycated amino acids--called glycation free adducts. The major effect on protein glycation in uremia is loss of clearance of glycation free adducts and their marked increase in plasma. Changes in glycation adduct residue content of plasma protein in uremia is, in contrast, relatively modest. There is now doubt as to whether the concept of interaction of advanced glycation endproduct (AGE)-modified proteins with putative AGE receptors can be sustained in vivo. A residual important feature of the receptor for AGEs may be decrease in expression of glyoxalase 1 of the antiglycation defence by S100A12 protein leaving the vasculature vulnerable to dicarbonyl stress and related AGE formation. The dicarbonyl proteome, proteins susceptible to dicarbonyl glycation at functional sites, is the likely mediator of glycation damage in uremia. Glycation of type IV collagen with shedding of endothelial cells and glycation of apolipoprotein B100 with increased atherogenicity of low density lipoprotein are two examples which may link protein glycation to increased risk of cardiovascular disease in end-stage renal disease.
AuthorsPaul J Thornalley, Naila Rabbani
JournalSeminars in dialysis (Semin Dial) 2009 Jul-Aug Vol. 22 Issue 4 Pg. 400-4 ISSN: 1525-139X [Electronic] United States
PMID19708990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Glycosylation End Products, Advanced
Topics
  • Cardiovascular Diseases (etiology, metabolism)
  • Glycosylation
  • Glycosylation End Products, Advanced (physiology)
  • Humans
  • Kidney Failure, Chronic (complications, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: