Abstract | OBJECTIVES: METHODS: A nested case-control study within the Nurses' Health Study was used to investigate an association between cSHMT (1420C --> T) and breast cancer risk. RESULTS: No evidence for an association between the cSHMT genotype and breast cancer was observed. There was also no evidence of a gene-gene interaction between cSHMT and MTHFR. CONCLUSIONS: There was no evidence of an association between the cSHMT genotype and breast cancer occurrence. Further research in populations with differing average folate intake may be required to fully understand the interactions of folate nutrition, sequence variation in folate genes and breast cancer risk.
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Authors | A R Bentley, F Raiszadeh, P J Stover, D J Hunter, S E Hankinson, P A Cassano |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 64
Issue 1
Pg. 108-10
(Jan 2010)
ISSN: 1476-5640 [Electronic] England |
PMID | 19707223
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Methylenetetrahydrofolate Reductase (NADPH2)
- Glycine Hydroxymethyltransferase
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Topics |
- Breast Neoplasms
(genetics)
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Glycine Hydroxymethyltransferase
(genetics)
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
(genetics)
- Nurses
- Odds Ratio
- Polymorphism, Single Nucleotide
- Risk Factors
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