A phase I study of a 2-day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound Paclitaxel for advanced solid malignancies.

Abstract

PURPOSE:

Systemic chemotherapy fails to access much of the tumor burden in patients with advanced cancer, significantly limiting its efficacy. In preclinical studies, brief high doses of tyrosine kinase inhibitors (TKI) targeting the human epidermal growth factor receptor (HER) family can prime tumor vasculature for optimal chemotherapeutic delivery and efficacy. This study investigates the clinical relevance of this approach.

EXPERIMENTAL DESIGN:

A phase I clinical study of escalating doses of the HER TKI lapatinib given as a 2-day pulse before a weekly infusion of nab-paclitaxel (100 mg/m(2)) was conducted in patients with advanced solid tumors.

RESULTS:

Twenty-five patients were treated. Treatment was associated with grade 1 to 2 toxicities including diarrhea, nausea, rash, neutropenia, neuropathy, fatigue, alopecia, and anemia. The two dose-limiting toxicities were grade 3 vomiting and grade 4 neutropenia, and the maximum tolerated dose of lapatinib was defined as 5250 mg/day in divided doses. Lapatinib concentrations increased with increasing dose. Dynamic Contrast Enhanced Magnetic Resonance Imaging studies in a subset of patients confirmed a decrease in tumor vascular permeability immediately following a lapatinib pulse. Sixty-five percent of evaluable patients experienced a partial or stable response on this therapy, 72% of whom were previously taxane-refractory.

CONCLUSION:

A 2-day pulse of high-dose lapatinib given before weekly nab-paclitaxel is a feasible and tolerable clinical regimen, suitable for testing this novel vascular-priming chemosensitization hypothesis developed in preclinical models.

• Authors: Amy J Chien, Julie A Illi, Andrew H Ko, Wolfgang M Korn, Lawrence Fong, Lee-may Chen, Mohammed Kashani-Sabet, Charles J Ryan, Jonathan E Rosenberg, Sarita Dubey, Eric J Small, Thierry M Jahan, Nola M Hylton, Benjamin M Yeh, Yong Huang, Kevin M Koch, Mark M Moasser
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 15 Issue 17 Pg. 5569-75 (Sep 01 2009) ISSN: 1557-3265 [Electronic] United States
• PMID: 19706807 (Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Albumin-Bound Paclitaxel
• Albumins
• Protein Kinase Inhibitors
• Quinazolines
• Lapatinib
• ErbB Receptors
• Paclitaxel

Topics

• Administration, Oral
• Albumin-Bound Paclitaxel
• Albumins (administration & dosage, adverse effects)
• Antineoplastic Combined Chemotherapy Protocols
• Dose-Response Relationship, Drug
• ErbB Receptors (metabolism)
• Female
• Humans
• Injections, Intravenous
• Lapatinib
• Male
• Middle Aged
• Nanoparticles (administration & dosage)
• Neoplasms (drug therapy, pathology)
• Paclitaxel (administration & dosage, adverse effects)
• Protein Kinase Inhibitors (administration & dosage, therapeutic use, toxicity)
• Quinazolines (administration & dosage, adverse effects)