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Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation.

Abstract
Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma (ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and corneal injuries almost disappeared. More than a year has passed since the transplantation was performed, and she has had no recurrence of either ATLL or lesions in the skin and eye. Her clinical course suggests a possible association between skin and eye lesions and HTLV-1 infection. Changes in the immunological condition after HSCT might play a key role. Special attention is needed when HTLV-1 carriers develop eye or skin lesions.
AuthorsFumiya Miyamura, Shinichi Kako, Hiroko Yamagami, Ken Sato, Miki Sato, Kiriko Terasako, Shun-Ichi Kimura, Hideki Nakasone, Satoko Aoki, Shinya Okuda, Rie Yamazaki, Kumi Oshima, Kentaro Yoshinaga, Takakazu Higuchi, Junji Nishida, Toshio Demitsu, Akihiro Kakehashi, Yoshinobu Kanda
JournalInternational journal of hematology (Int J Hematol) Vol. 90 Issue 3 Pg. 397-401 (Oct 2009) ISSN: 1865-3774 [Electronic] Japan
PMID19705056 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Chronic Disease
  • Corneal Diseases (complications, therapy, virology)
  • Eczema (complications, therapy, virology)
  • Female
  • HTLV-I Infections (complications)
  • Hematopoietic Stem Cell Transplantation
  • Human T-lymphotropic virus 1
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell (complications, therapy, virology)
  • Transplantation, Homologous
  • Treatment Outcome
  • Viral Load

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