Abstract |
Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma ( ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and corneal injuries almost disappeared. More than a year has passed since the transplantation was performed, and she has had no recurrence of either ATLL or lesions in the skin and eye. Her clinical course suggests a possible association between skin and eye lesions and HTLV-1 infection. Changes in the immunological condition after HSCT might play a key role. Special attention is needed when HTLV-1 carriers develop eye or skin lesions.
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Authors | Fumiya Miyamura, Shinichi Kako, Hiroko Yamagami, Ken Sato, Miki Sato, Kiriko Terasako, Shun-Ichi Kimura, Hideki Nakasone, Satoko Aoki, Shinya Okuda, Rie Yamazaki, Kumi Oshima, Kentaro Yoshinaga, Takakazu Higuchi, Junji Nishida, Toshio Demitsu, Akihiro Kakehashi, Yoshinobu Kanda |
Journal | International journal of hematology
(Int J Hematol)
Vol. 90
Issue 3
Pg. 397-401
(Oct 2009)
ISSN: 1865-3774 [Electronic] Japan |
PMID | 19705056
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Chronic Disease
- Corneal Diseases
(complications, therapy, virology)
- Eczema
(complications, therapy, virology)
- Female
- HTLV-I Infections
(complications)
- Hematopoietic Stem Cell Transplantation
- Human T-lymphotropic virus 1
- Humans
- Leukemia-Lymphoma, Adult T-Cell
(complications, therapy, virology)
- Transplantation, Homologous
- Treatment Outcome
- Viral Load
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