[The Ca2+ reactivity and the subunit composition of myocardial actomyosin during the pyromecaine and pyrroxan treatment of experimental ischemia].

Abstract

The treatment with pyromecaine and pyrroxan for 5 days was found to prevent disturbances of the physicochemical properties and the composition of the components of actomyosin complex of the rat heart left ventricle caused by experimental myocardial ischemia. Pyrroxan is able to change also the gene expression thereby leading to the appearance of a new isoform of myocardial myosin reminding by its characteristics the isoform of myosin of the rapidly contracting skeletal muscles.

• Authors: M A Kaĭfadzhian, E G Dzhanpoladian
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Jan-Feb Vol. 53 Issue 1 Pg. 27-30 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Ca2+-reaktivnost' i sub''edinichnyĭ sostav aktomiozina miokarda pri lechenii éksperimental'noĭ ishemii piromekainom i pirroksanom.
• PMID: 1970309 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Anti-Arrhythmia Agents
• Dioxanes
• Dioxins
• Peptide Fragments
• Pyrrolidines
• bumecain
• Actomyosin
• Calcium
• proroxan

Topics

• Actomyosin (drug effects, metabolism)
• Adrenergic alpha-Antagonists (therapeutic use)
• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Calcium (metabolism)
• Coronary Disease (drug therapy, metabolism)
• Dioxanes (therapeutic use)
• Dioxins (therapeutic use)
• Drug Evaluation, Preclinical
• Heart (drug effects)
• Male
• Myocardium (metabolism)
• Peptide Fragments (drug effects, metabolism)
• Pyrrolidines (therapeutic use)
• Rats