Disubstituted 4(3H) quinazolones: a novel class of antitumor agents.

Abstract

A series of disubstituted 4(3H) quinazolines were designed for potential application in tumors. Firstly, N-benzoyl anthranilic acid is formed, which undergoes cyclization in the presence of pyridine. Subsequently, nucleophilic attack by semicarbazide on the carbonyl carbon gives 2-substituted 3-carbamido 4(3H) quinazolones, which gives final compound with appropriate substitution. The final as well as intermediate products were confirmed by NMR, FT-IR, and mass spectrometry. In vitro toxicity was performed with different cell lines and showed that the connection of hydrophilic styryl to quinazoline moiety increases its efficacy.

• Authors: Vikas Srivastava, Anand Mohan Srivastava, Anjani K Tiwari, Rakesh Srivastava, Rajbala Sharma, Himanshu Sharma, Vinay K Singh
• Journal: Chemical biology & drug design (Chem Biol Drug Des) Vol. 74 Issue 3 Pg. 297-301 (Sep 2009) ISSN: 1747-0285 [Electronic] England
• PMID: 19703032 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Quinazolines

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, toxicity)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Humans
• Neoplasms (drug therapy)
• Quantitative Structure-Activity Relationship
• Quinazolines (chemical synthesis, chemistry, toxicity)