Abstract |
A series of disubstituted 4(3H) quinazolines were designed for potential application in tumors. Firstly, N-benzoyl anthranilic acid is formed, which undergoes cyclization in the presence of pyridine. Subsequently, nucleophilic attack by semicarbazide on the carbonyl carbon gives 2-substituted 3-carbamido 4(3H) quinazolones, which gives final compound with appropriate substitution. The final as well as intermediate products were confirmed by NMR, FT-IR, and mass spectrometry. In vitro toxicity was performed with different cell lines and showed that the connection of hydrophilic styryl to quinazoline moiety increases its efficacy.
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Authors | Vikas Srivastava, Anand Mohan Srivastava, Anjani K Tiwari, Rakesh Srivastava, Rajbala Sharma, Himanshu Sharma, Vinay K Singh |
Journal | Chemical biology & drug design
(Chem Biol Drug Des)
Vol. 74
Issue 3
Pg. 297-301
(Sep 2009)
ISSN: 1747-0285 [Electronic] England |
PMID | 19703032
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Quinazolines
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, toxicity)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Humans
- Neoplasms
(drug therapy)
- Quantitative Structure-Activity Relationship
- Quinazolines
(chemical synthesis, chemistry, toxicity)
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