Biological properties of a CD4 immunoadhesin.

Abstract

Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.

• Authors: R A Byrn, J Mordenti, C Lucas, D Smith, S A Marsters, J S Johnson, P Cossum, S M Chamow, F M Wurm, T Gregory, J E Groopman, D J Capon
• Journal: Nature (Nature) Vol. 344 Issue 6267 Pg. 667-70 (Apr 12 1990) ISSN: 0028-0836 [Print] England
• PMID: 1970124 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Anti-Idiotypic
• Antigens, CD
• CD4 Immunoadhesins
• HIV Envelope Protein gp120
• Immunoglobulin G
• Recombinant Proteins

Topics

• Acquired Immunodeficiency Syndrome (congenital, immunology)
• Animals
• Antibodies, Anti-Idiotypic (immunology)
• Antibody-Dependent Cell Cytotoxicity (immunology)
• Antigens, CD (immunology)
• CD4 Immunoadhesins
• CD4-Positive T-Lymphocytes (immunology, microbiology)
• Female
• HIV (immunology)
• HIV Envelope Protein gp120 (immunology)
• Humans
• Immunity, Maternally-Acquired
• Immunoglobulin G (immunology)
• Macaca mulatta
• Pregnancy
• Recombinant Proteins