Abstract |
The present study investigated the potential efficacy of buspirone for treating marijuana dependence. Participants received either buspirone (maximum 60mg/day) (n=23) or matching placebo (n=27) for 12 weeks, each in conjunction with motivational interviewing. In the modified intention-to-treat analysis, the percentage of negative UDS results in the buspirone-treatment group was 18 percentage points higher than the placebo-treatment group (95% CI: -2% to 37%, p=0.071). On self-report, participants receiving buspirone reported not using marijuana 45.2% of days and participants receiving placebo reported not using 51.4% of days (p=0.55). An analysis of participants that completed the 12-week trial showed a significant difference in the percentage negative UDS (95% CI: 7-63%, p=0.014) and a trend for participants randomized to the buspirone-treatment group who completed treatment to achieve the first negative UDS result sooner than those participants treated with placebo (p=0.054). Further study with buspirone in this population may be warranted; however, strategies to enhance study retention and improve outcome measurement should be considered in future trials.
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Authors | Aimee L McRae-Clark, Rickey E Carter, Therese K Killeen, Matthew J Carpenter, Amy E Wahlquist, Stacey A Simpson, Kathleen T Brady |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 105
Issue 1-2
Pg. 132-8
(Nov 01 2009)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 19699593
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-Anxiety Agents
- Cannabinoids
- Buspirone
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Topics |
- Adult
- Anti-Anxiety Agents
(adverse effects, therapeutic use)
- Anxiety
(drug therapy, etiology, psychology)
- Buspirone
(adverse effects, therapeutic use)
- Cannabinoids
(urine)
- Cannabis
(adverse effects)
- Double-Blind Method
- Female
- Humans
- Male
- Marijuana Abuse
(drug therapy, psychology, urine)
- Motivation
- Psychiatric Status Rating Scales
- Sample Size
- Substance Withdrawal Syndrome
(epidemiology, psychology)
- Surveys and Questionnaires
- Treatment Outcome
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