HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A placebo-controlled trial of buspirone for the treatment of marijuana dependence.

Abstract
The present study investigated the potential efficacy of buspirone for treating marijuana dependence. Participants received either buspirone (maximum 60mg/day) (n=23) or matching placebo (n=27) for 12 weeks, each in conjunction with motivational interviewing. In the modified intention-to-treat analysis, the percentage of negative UDS results in the buspirone-treatment group was 18 percentage points higher than the placebo-treatment group (95% CI: -2% to 37%, p=0.071). On self-report, participants receiving buspirone reported not using marijuana 45.2% of days and participants receiving placebo reported not using 51.4% of days (p=0.55). An analysis of participants that completed the 12-week trial showed a significant difference in the percentage negative UDS (95% CI: 7-63%, p=0.014) and a trend for participants randomized to the buspirone-treatment group who completed treatment to achieve the first negative UDS result sooner than those participants treated with placebo (p=0.054). Further study with buspirone in this population may be warranted; however, strategies to enhance study retention and improve outcome measurement should be considered in future trials.
AuthorsAimee L McRae-Clark, Rickey E Carter, Therese K Killeen, Matthew J Carpenter, Amy E Wahlquist, Stacey A Simpson, Kathleen T Brady
JournalDrug and alcohol dependence (Drug Alcohol Depend) Vol. 105 Issue 1-2 Pg. 132-8 (Nov 01 2009) ISSN: 1879-0046 [Electronic] Ireland
PMID19699593 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
Chemical References
  • Anti-Anxiety Agents
  • Cannabinoids
  • Buspirone
Topics
  • Adult
  • Anti-Anxiety Agents (adverse effects, therapeutic use)
  • Anxiety (drug therapy, etiology, psychology)
  • Buspirone (adverse effects, therapeutic use)
  • Cannabinoids (urine)
  • Cannabis (adverse effects)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Marijuana Abuse (drug therapy, psychology, urine)
  • Motivation
  • Psychiatric Status Rating Scales
  • Sample Size
  • Substance Withdrawal Syndrome (epidemiology, psychology)
  • Surveys and Questionnaires
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: