Abstract | BACKGROUND: METHODS: Follicular integrity and hair growth was assessed in male and female SD neonatal rats (8 days old) treated with a single dose of Ara-C (30 mg/kg/day, i.p.) and AHCC (500 mg/kg/day, p.o.) for 7 consecutive days. The side effects of a single oral dose of 6-MP (2.5mg/kg body weight) plus MTX (30 mg/kg body weight) and their amelioration by treatment with AHCC (1000 mg/kg body weight) for 28 days were assessed in male ddY mice (8 weeks old). RESULTS: CONCLUSION: Co-administration of AHCC significantly reduced the side effects associated with Ara-C, 6-MP and MTX. However, the molecular mechanism for AHCC activity and its clinical integrity for use needs defining.
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Authors | Buxiang Sun, Koji Wakame, Eri Sato, Hiroshi Nishioka, Okezie I Aruoma, Hajime Fujii |
Journal | Cancer epidemiology
(Cancer Epidemiol)
Vol. 33
Issue 3-4
Pg. 293-9
(Oct 2009)
ISSN: 1877-783X [Electronic] Netherlands |
PMID | 19699163
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Polysaccharides
- Cytarabine
- Mercaptopurine
- Active Hexose Correlated Compound
- Methotrexate
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Topics |
- Alopecia
(chemically induced, drug therapy)
- Animals
- Animals, Newborn
- Antimetabolites, Antineoplastic
(adverse effects)
- Body Weight
(drug effects)
- Cytarabine
(adverse effects)
- Female
- Hair Follicle
(drug effects, pathology)
- Male
- Mercaptopurine
(adverse effects)
- Methotrexate
(adverse effects)
- Mice
- Polysaccharides
(isolation & purification, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Shiitake Mushrooms
(chemistry)
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