Expression of Twist in different subtype of ameloblastomas.

Abstract

OBJECTIVE:

The objective of this study was to investigate the pattern of Twist expression in a series of ameloblastomas, and to study the possible role of Twist in the bone destruction and local invasiveness of ameloblastoma variants.

STUDY DESIGN:

Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]).

RESULTS:

The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05). Both nuclei and cytoplasm positivities were detected in positive cases, whereas cytoplasmic staining was diffused and predominant. Cases rich in stromal cells showed a higher percentage of positive cells than those with less stroma.

CONCLUSIONS:

Our results suggest that Twist expression might be associated with invasion in ameloblastoma variants, and stromal cells might play a regulatory role during tumor development.

• Authors: Yang Feng, Yin-Mei Zhou, Cheng-Ge Hua, Xiu-Fa Tang, Deng-Qi He
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 108 Issue 4 Pg. 565-70 (Oct 2009) ISSN: 1528-395X [Electronic] United States
• PMID: 19699120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nuclear Proteins
• TWIST1 protein, human
• Twist-Related Protein 1

Topics

• Ameloblastoma (classification, pathology)
• Cell Nucleus (ultrastructure)
• Cytoplasm (ultrastructure)
• Epithelial Cells (pathology)
• Humans
• Image Processing, Computer-Assisted
• Immunohistochemistry
• Jaw Neoplasms (classification, pathology)
• Neoplasm Invasiveness
• Nuclear Proteins (analysis)
• Stromal Cells (pathology)
• Twist-Related Protein 1 (analysis)