[Tyrosine kinase mutation and acute myeloid leukemia with T (8; 21)].

Abstract

This study was aimed to investigate the status of c-KIT, Fms-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) mutations in acute myeloid leukemia (AML) patients with t (8; 21) and to analyze their relation to clinical feature and prognosis. PCR, AS-PCR, restriction and sequencing methods were used respectively to detect the FLT3, JAK 2 and c-KIT mutations in 8 cases of de novo AML with t (8; 21) and 6 cases of relapsed AML with t (8; 21). The results showed that the c-KIT mutation was found in 2 cases out of 14 AML patients with t (8; 21) (14.3%), among them 1 case had c-KIT D816V mutation, the other had c-KIT D816Y mutation. The FLT3-ITD mutation was detect in 1 out of 14 patients (7.1%), but JAK2 mutation could not be detected in all 14 cases. In conclusion, tyrosine kinase mutation relates to AML with t (8; 21), patients with tyrosine kinase mutation may have higher relapse, extramedullary infiltration and poor prognosis. The screening c-KIT, FLT3 mutations may play an important role in evaluating prognosis and guiding treatment of t (8; 21) AML.

• Authors: Yang-Li Han, Su-Jiang Zhang, Chun Qiao, Dan Dai, Xue-Mei Sun, Yan-Li Xu, Si-Xuan Qian, Wei Xu, Ji-Shi Wang, Jian-Yong Li
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 17 Issue 4 Pg. 866-9 (Aug 2009) ISSN: 1009-2137 [Print] China
• PMID: 19698218 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• FLT3 protein, human
• Proto-Oncogene Proteins c-kit
• fms-Like Tyrosine Kinase 3
• JAK2 protein, human
• Janus Kinase 2

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Female
• Humans
• Janus Kinase 2 (genetics)
• Leukemia, Myeloid, Acute (genetics)
• Male
• Middle Aged
• Mutation
• Proto-Oncogene Proteins c-kit (genetics)
• Tandem Repeat Sequences
• Young Adult
• fms-Like Tyrosine Kinase 3 (genetics)