Abstract |
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects. We found that gp120 was present in high concentrations (>300 pg/mL) in the spleen and lymph nodes of some of these individuals. In contrast, very low amounts of gp120 and p24 were detected in all serum samples tested. These findings underpin the clinical relevance of nonentry functions of gp120 and the chronic nature of human immunodeficiency virus (HIV)-induced immune dysregulation.
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Authors | Michael Santosuosso, Elda Righi, Victoria Lindstrom, Pierre R Leblanc, Mark C Poznansky |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 200
Issue 7
Pg. 1050-3
(Oct 01 2009)
ISSN: 0022-1899 [Print] United States |
PMID | 19698075
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- HIV Envelope Protein gp120
- gp120 protein, Human immunodeficiency virus 1
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Topics |
- Aged
- Chronic Disease
- Female
- HIV Envelope Protein gp120
(analysis, blood)
- HIV Infections
(metabolism)
- Humans
- Lymph Nodes
(chemistry)
- Male
- Middle Aged
- Spleen
(chemistry)
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