HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection.

Abstract
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects. We found that gp120 was present in high concentrations (>300 pg/mL) in the spleen and lymph nodes of some of these individuals. In contrast, very low amounts of gp120 and p24 were detected in all serum samples tested. These findings underpin the clinical relevance of nonentry functions of gp120 and the chronic nature of human immunodeficiency virus (HIV)-induced immune dysregulation.
AuthorsMichael Santosuosso, Elda Righi, Victoria Lindstrom, Pierre R Leblanc, Mark C Poznansky
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 200 Issue 7 Pg. 1050-3 (Oct 01 2009) ISSN: 0022-1899 [Print] United States
PMID19698075 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • HIV Envelope Protein gp120
  • gp120 protein, Human immunodeficiency virus 1
Topics
  • Aged
  • Chronic Disease
  • Female
  • HIV Envelope Protein gp120 (analysis, blood)
  • HIV Infections (metabolism)
  • Humans
  • Lymph Nodes (chemistry)
  • Male
  • Middle Aged
  • Spleen (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: