Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms?

Abstract

An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3-acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.

• Authors: Lv Wang, Manya T Angley, Jacobus P Gerber, Robyn L Young, Damien V Abarno, Ross A McKinnon, Michael J Sorich
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 14 Issue 8 Pg. 596-603 (Dec 2009) ISSN: 1366-5804 [Electronic] England
• PMID: 19697973 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• indolylacryloylglycine
• Creatinine
• Glycine

Topics

• Autistic Disorder (complications, urine)
• Biomarkers
• Child
• Child Development Disorders, Pervasive (diagnosis, urine)
• Creatinine (urine)
• Female
• Gastrointestinal Diseases (complications, urine)
• Glycine (analogs & derivatives, urine)
• Humans
• Male