Abstract | AIMS: To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p.Arg19Lys or c.56 G-->A (rs17183814) in north Indian epilepsy patients. METHODS: RESULTS: AG genotype of SCN1A 3184 A-->G polymorphism was significantly higher and associated in epilepsy patients [P= 0.005; odds ratio (OR) 1.76, 95% confidence interval (CI) 1.19, 2.61], whereas A variant of SCN2A c.56 G-->A was associated with multiple drug resistance in north Indian patients with epilepsy (P= 0.03; OR 1.62, 95% CI 1.03, 2.56). CONCLUSIONS: Overall, results indicate a differential role of genetic polymorphisms of sodium channels SCN1A and SCN2A in epilepsy susceptibility and drug response.
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Authors | Ram Lakhan, Ritu Kumari, Usha K Misra, Jayanti Kalita, Sunil Pradhan, Balraj Mittal |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 68
Issue 2
Pg. 214-20
(Aug 2009)
ISSN: 1365-2125 [Electronic] England |
PMID | 19694741
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Asian People
- Drug Resistance, Multiple
(drug effects, genetics)
- Epilepsy
(drug therapy, genetics)
- Female
- Genetic Predisposition to Disease
(genetics)
- Genetic Variation
- Genotype
- Humans
- Male
- Phenotype
- Polymorphism, Genetic
- Reference Values
- Sodium Channels
(drug effects, genetics)
- Young Adult
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