[Inhibition of the metastasis of Lewis lung carcinoma in mice by the administration of spasmolytin, midantan and L-DOPA].

Abstract

Different combinations and doses of neurotropic drugs of the central action (spasmolytine, midantane, L-DOPA) coupled with the surgical removal of the lung Lewis carcinoma were studied for their effect on the metastatic spreading in C57BL/6 mice. It has been established that the long-term use of spasmolytine and midantane before and after the operation inhibits the metastatic process, that is expressed in the total volume reduction of lung metastases, lack of metastases in a number of mice and augmentation of the average life. Such method of drug application is more effective in the metastatic growth inhibition as against their application only in the pre- or postoperation periods as well as with the use of the other neurotropic drug combinations.

• Authors: A V Syromiatnikov, A V Alistratov, K P Balitskiĭ
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 12 Issue 2 Pg. 62-6 ( 1990) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Tormozhenie metastazirovaniia kartsinomy legkogo L'iuis u mysheĭ pri vvedenii spazmolitina, midantana i L-DOFA.
• PMID: 1969341 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Diphenylacetic Acids
• Levodopa
• Amantadine

Topics

• Amantadine (therapeutic use)
• Animals
• Combined Modality Therapy
• Diphenylacetic Acids (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Levodopa (therapeutic use)
• Lung Neoplasms (drug therapy, mortality, surgery)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis
• Neoplasm Transplantation
• Postoperative Care
• Preoperative Care