Abstract | BACKGROUND: METHODS: : A panel of 962 breast cancers was stained for 5 markers (ER, PR, HER-2/neu, CK5/CK6, and EGFR). The patients were followed for clinical outcomes for up to 15 years from diagnosis, and the rates of distant disease recurrence and death were compared by tumor size (< or =2 cm or >2 cm) and by lymph node status within the subgroups of women with basal and nonbasal cancers. RESULTS: : Of the 962 women with breast cancer, 116 cancers were basal (12%), 845 were nonbasal (88%), and 1 could not be classified as either basal or nonbasal and was excluded. In total, 426 tumors measured < or =2 cm (45%), and 530 tumors measured >2 cm (55%). Among women with nonbasal cancers, large tumor size was an adverse prognostic factor. Among women with basal cancers, a transient adverse effect of size on disease recurrence was observed; however, after 10 years, mortality rates were equal for women with small tumors and women with large tumors. CONCLUSIONS: : Among women with basal breast cancers, the long-term prognosis was similar for women with large tumors and women with small tumors. However, women with large basal tumors appeared to develop recurrent disease sooner. Cancer 2009. (c) 2009 American Cancer Society.
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Authors | Rebecca Dent, Wedad M Hanna, Maureen Trudeau, Ellen Rawlinson, Ping Sun, Steven A Narod |
Journal | Cancer
(Cancer)
Vol. 115
Issue 21
Pg. 4917-23
(Nov 01 2009)
ISSN: 0008-543X [Print] United States |
PMID | 19691094
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(classification, mortality, pathology)
- Disease-Free Survival
- Female
- Humans
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Recurrence, Local
- Neoplasms, Hormone-Dependent
(mortality, pathology)
- Predictive Value of Tests
- Prognosis
- Time Factors
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