Alpha-ketoglutarate and postoperative muscle catabolism.

Abstract

The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.

• Authors: J Wernerman, F Hammarqvist, E Vinnars
• Journal: Lancet (London, England) (Lancet) Vol. 335 Issue 8691 Pg. 701-3 (Mar 24 1990) ISSN: 0140-6736 [Print] England
• PMID: 1969067 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ketoglutaric Acids
• Muscle Proteins
• Glutamine
• Nitrogen

Topics

• Cholecystectomy
• Drug Evaluation
• Glutamine (metabolism)
• Humans
• Ketoglutaric Acids (administration & dosage, pharmacology)
• Muscle Proteins (metabolism)
• Nitrogen (urine)
• Parenteral Nutrition, Total
• Postoperative Period
• Ribosomes (metabolism)