Abstract |
The hypnotic efficacy of estazolam, a triazolobenzodiazepine, has been established in well-controlled sleep laboratory and outpatient clinical trials. Estazolam 1.0 mg and 2.0 mg significantly improves sleep latency, total sleep time, number of nocturnal awakenings, depth of sleep, and sleep quality in adults with chronic insomnia. Long-term studies indicate that estazolam 2.0 mg remains an effective hypnotic for at least six weeks of continuous nightly administration with no evidence of clinically significant tolerance. Estazolam is an effective treatment for situational insomnia and significantly improves sleep in patients with insomnia associated with moderately severe anxiety or depression.
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Authors | M W Pierce, V S Shu |
Journal | The American journal of medicine
(Am J Med)
Vol. 88
Issue 3A
Pg. 6S-11S
(Mar 02 1990)
ISSN: 0002-9343 [Print] United States |
PMID | 1968721
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Anti-Anxiety Agents
- Placebos
- Estazolam
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Anxiety Agents
(therapeutic use)
- Anxiety Disorders
(drug therapy)
- Chronic Disease
- Clinical Trials as Topic
- Depressive Disorder
(drug therapy)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Estazolam
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Placebos
- Sleep
(drug effects)
- Sleep Initiation and Maintenance Disorders
(drug therapy)
- Time Factors
- United States
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