Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.

Abstract	Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.
Authors	Patel Mohanakumara, Nambiar Sreejayan, Vaidayanathan Priti, Bheemanahally Thimmappa Ramesha, Gudasalamani Ravikanth, Kotiganahalli Narayanagowda Ganeshaiah, Ramesh Vasudeva, John Mohan, Thankayyan Retnabai Santhoshkumar, Prabhu Dutt Mishra, Viswakarma Ram, Ramanan Uma Shaanker
Journal	Fitoterapia (Fitoterapia) Vol. 81 Issue 2 Pg. 145-8 (Mar 2010) ISSN: 1873-6971 [Electronic] Netherlands
PMID	19686817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	2009 Elsevier B.V. All rights reserved.
Chemical References	Antineoplastic Agents, Phytogenic Flavonoids Limonins Piperidines Plant Extracts Protein Kinase Inhibitors alvocidib rohitukin
Topics	Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use) Breast Neoplasms (drug therapy) Cell Line, Tumor Female Flavonoids (pharmacology, therapeutic use) Humans India Limonins (isolation & purification, therapeutic use) Meliaceae (chemistry) Neoplasms (drug therapy) Ovarian Neoplasms (drug therapy) Phytotherapy Piperidines (pharmacology, therapeutic use) Plant Bark Plant Extracts (chemistry, isolation & purification, therapeutic use) Plant Stems Protein Kinase Inhibitors (isolation & purification, pharmacology, therapeutic use) Trees (chemistry)

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