Lumcorin: a leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration.

Abstract

We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.

• Authors: Cédric Zeltz, Stéphane Brézillon, Corinne Perreau, Laurent Ramont, François-Xavier Maquart, Yanusz Wegrowski
• Journal: FEBS letters (FEBS Lett) Vol. 583 Issue 18 Pg. 3027-32 (Sep 17 2009) ISSN: 1873-3468 [Electronic] England
• PMID: 19686741 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chondroitin Sulfate Proteoglycans
• LUM protein, human
• Lumican
• Peptide Fragments
• lumcorin
• Keratan Sulfate

Topics

• Apoptosis (drug effects)
• Catalytic Domain
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Survival (drug effects)
• Chondroitin Sulfate Proteoglycans (chemistry, pharmacology, therapeutic use)
• Humans
• Keratan Sulfate (chemistry, therapeutic use)
• Lumican
• Melanoma (drug therapy, pathology)
• Peptide Fragments (pharmacology, therapeutic use)