Abstract | BACKGROUND AND AIM: METHODS: RESULTS: After terlipressin, there were significant increases in both mean arterial pressure (P < 0.001) and systemic vascular resistance (P < 0.001), whereas heart rate (P < 0.001) and cardiac output (P < 0.001) decreased significantly. There was a significant decrease in the hepatic venous pressure gradient (P < 0.001). Portal venous blood flow also decreased significantly (P < 0.001). The mean hepatic arterial velocity increased significantly (P < 0.001). Although there was a significant decrease in the hepatic arterial resistive index (0.72 +/- 0.08 to 0.69 +/- 0.08, P < 0.001) and renal arterial resistive index (0.74 +/- 0.07 to 0.68 +/- 0.07, P < 0.001), portal vascular resistance was unchanged (P = 0.231). Plasma renin activity decreased significantly (P < 0.005), and there was a significant correlation between this decline and the decrease in renal arterial resistive index (r = 0.764, P < 0.005). The effects of terlipressin on systemic, hepatic and renal hemodynamics were observed similarly in patients with and without ascites. Placebo caused no significant effects. CONCLUSION:
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Authors | Yoshiyuki Narahara, Hidenori Kanazawa, Yasuhiko Taki, Yuu Kimura, Masanori Atsukawa, Tamaki Katakura, Hideko Kidokoro, Hirotomo Harimoto, Takeshi Fukuda, Yoko Matsushita, Katsuhisa Nakatsuka, Choitsu Sakamoto |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 24
Issue 11
Pg. 1791-7
(Nov 2009)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 19686420
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Neurotransmitter Agents
- Vasoconstrictor Agents
- Lypressin
- Terlipressin
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Topics |
- Aged
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Female
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Hepatorenal Syndrome
(diagnostic imaging, drug therapy, etiology, physiopathology)
- Humans
- Hypertension, Portal
(diagnostic imaging, drug therapy, etiology, physiopathology)
- Injections, Intravenous
- Liver Circulation
(drug effects)
- Liver Cirrhosis
(complications, diagnostic imaging, drug therapy, physiopathology)
- Lypressin
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Neurotransmitter Agents
(blood)
- Placebo Effect
- Renal Circulation
(drug effects)
- Terlipressin
- Treatment Outcome
- Ultrasonography, Doppler
- Vascular Resistance
(drug effects)
- Vasoconstrictor Agents
(administration & dosage, adverse effects, therapeutic use)
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