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Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population.

Abstract
Recent studies showing the improvement of ADHD symptoms obtained with the highly selective noradrenergic reuptake inhibitor, atomoxetine, demonstrate that the noradrenergic system plays the role of pathophysiology in this disorder. It is revealed that the norepinephrine transporter gene (SLC6A2) is a possible candidate gene directly related to ADHD. To determine possible roles of the SLC6A2 as a susceptibility gene for ADHD, we performed the genetic association study for a functional -3081(A/T) polymorphism, located in the promoter region of SLC6A2. For the present study of association between ADHD and the SLC6A2, 103 male patients with ADHD and 103 normal male controls were randomly gathered. Significant differences were found in the allele frequencies (chi(2) = 5.60, P = 0.02) and the odds ratio for the allele T between the ADHD and normal subjects was 1.59 (95% CI: 1.08-2.34) suggesting that T allele is critical to make the group difference. Significant group difference was also found in AA, AT, TT genotypes (chi(2) = 7.1, P = 0.02). The odds ratio for TT and AT genotypes was 4.57 (95% CI: 2.56-8.15) and 1.96 (95% CI: 0.96-3.78), respectively. Findings in the present study provided further evidence of association between ADHD and -3081(A/T) polymorphism of SLC6A2.
AuthorsYoosook Joung, Chun-Hyung Kim, Jisook Moon, Won-Seok Jang, Jaewon Yang, Dongwon Shin, Soonyoung Lee, Kwang-Soo Kim
JournalAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 153B Issue 2 Pg. 691-694 (Mar 05 2010) ISSN: 1552-485X [Electronic] United States
PMID19685476 (Publication Type: Journal Article)
Copyright(c) 2009 Wiley-Liss, Inc.
Chemical References
  • Norepinephrine Plasma Membrane Transport Proteins
  • SLC6A2 protein, human
Topics
  • Alleles
  • Attention Deficit Disorder with Hyperactivity (genetics)
  • Case-Control Studies
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Korea
  • Male
  • Norepinephrine Plasma Membrane Transport Proteins (genetics)
  • Odds Ratio
  • Polymorphism, Genetic
  • Promoter Regions, Genetic
  • Regression Analysis

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