Abstract | OBJECTIVE: METHODS: We investigated the relationship of the STAT4 rs7574865 and TNFRSF1B rs1061622 polymorphisms to SLE risk with special reference to their combination and interaction with cigarette smoking among 152 SLE cases and 427 controls. RESULTS: The TT genotype of STAT4 rs7574865 was significantly associated with increased risk of SLE (OR 2.21, 95% CI 1.10-4.68). Subjects with at least one G allele of TNFRSF1B rs1061622 had an increased risk of SLE (OR 1.56, 95% CI 0.99-2.47). The attributable proportion due to the interaction between the TNFRSF1B rs1061622 genotypes and smoking was estimated to be 0.49 (95% CI 0.07-0.92), indicating that 49% of the excess risk for SLE in smokers with at least one G allele was due to an additive interaction. A lack of significant associations of STAT4 with smoking was observed. No significant gene-gene interactions were found among polymorphisms of STAT4 and TNFRSF1B. CONCLUSION: Our findings suggest that the association between cigarette smoking and SLE could be differentiated by the TNFRSF1B rs1061622 T allele among female Japanese subjects. This preliminary exploratory result should be confirmed in a larger study.
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Authors | Chikako Kiyohara, Masakazu Washio, Takahiko Horiuchi, Yoshifumi Tada, Toyoko Asami, Saburo Ide, Tatsuya Atsumi, Gen Kobashi, Hiroki Takahashi, Kyushu Sapporo SLE (KYSS) Study Group |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 36
Issue 10
Pg. 2195-203
(Oct 2009)
ISSN: 0315-162X [Print] Canada |
PMID | 19684152
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Tumor Necrosis Factor, Type II
- STAT4 Transcription Factor
- STAT4 protein, human
- TNFRSF1B protein, human
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Topics |
- Adult
- Alleles
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
(ethnology, genetics)
- Genotype
- Humans
- Japan
- Lupus Erythematosus, Systemic
(ethnology, genetics)
- Middle Aged
- Polymorphism, Genetic
(genetics)
- Receptors, Tumor Necrosis Factor, Type II
(genetics)
- Risk Factors
- STAT4 Transcription Factor
(genetics)
- Smoking
(adverse effects)
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