Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm.

Abstract

Lysyl oxidase (LOX) is an enzyme critical for the stability of extracellular matrix and also known to have diverse biological functions. Little is known, however, about the role of LOX in regulating inflammation. Here we demonstrate that LOX suppresses secretion of monocyte chemoattractant protein-1 (MCP-1) in cultured vascular smooth muscle cells. Furthermore, enhancement of LOX activity reduces MCP-1 in a mouse model of abdominal aortic aneurysm (AAA), thereby preventing macrophage infiltration and AAA progression. These findings suggest that LOX has a novel function in resolving inflammation by reducing MCP-1 in AAA.

• Authors: Masahiko Onoda, Koichi Yoshimura, Hiroki Aoki, Yasuhiro Ikeda, Noriyasu Morikage, Akira Furutani, Masunori Matsuzaki, Kimikazu Hamano
• Journal: Atherosclerosis (Atherosclerosis) Vol. 208 Issue 2 Pg. 366-9 (Feb 2010) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 19683237 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Chemokine CCL2
• Cytokines
• Protein-Lysine 6-Oxidase

Topics

• Adenoviridae (metabolism)
• Animals
• Aortic Aneurysm, Abdominal (metabolism, therapy)
• Chemokine CCL2 (metabolism)
• Cytokines (metabolism)
• Disease Progression
• Inflammation
• Macrophages (metabolism)
• Male
• Mice
• Muscle, Smooth, Vascular (cytology)
• Protein-Lysine 6-Oxidase (metabolism, physiology)
• Rats
• Rats, Wistar
• Reverse Transcriptase Polymerase Chain Reaction